Which combination increases cellular radiosensitivity according to Bergonie and Tribondeau?

Which combination increases cellular radiosensitivity according to Bergonie and Tribondeau?

• A. Young, Rapidly Dividing, Undifferentiated
• B. Old, Mature, Differentiated
• C. Quiescent Cells With Short Lifespan
• D. Post-Mitotic Neurons

Answer: (A)

Radiosensitivity depends on how actively a cell is dividing, how differentiated it is, and how much future cell division it has. Bergonie and Tribondeau showed that cells with high mitotic activity, that are undifferentiated, and that have a long potential for division are the most radiosensitive. So a young cell that is rapidly dividing and not yet specialized fits all three factors, making it the most susceptible to radiation damage. In contrast, older, mature, differentiated cells divide rarely and have limited division potential, which makes them more resistant. Quiescent cells and post‑mitotic neurons are not actively dividing, so they are even less radiosensitive.

Radiosensitivity depends on how actively a cell is dividing, how differentiated it is, and how much future cell division it has. Bergonie and Tribondeau showed that cells with high mitotic activity, that are undifferentiated, and that have a long potential for division are the most radiosensitive. So a young cell that is rapidly dividing and not yet specialized fits all three factors, making it the most susceptible to radiation damage. In contrast, older, mature, differentiated cells divide rarely and have limited division potential, which makes them more resistant. Quiescent cells and post‑mitotic neurons are not actively dividing, so they are even less radiosensitive.